High-Throughput Interaction Data Matrix Analysis

About

The High Throughput Interaction Data Handler is a web application specialized in handling and transforming in various ways data matrices, with a strong bias on protein-protein/protein-peptide quantitative interaction data. Such data are generally available as matrices, with proteins or protein domains representing the columns and peptides or other proteins representing the lines. For each intersection, a value is present, representing the strength of interaction/affinity between the two putative interacting partners. This situation is tipical in "PepSpot" experiments.

Thanks to the high-throughput nature of the techniques presently available, these data matrices can be huge. Although many operations with this kind of data matrix can be performed with programs such as Excel, many other more specialized tasks, for example the extraction from such a matrix of a properly formatted file to be fed into interaction network analysis programs (eg: cytoscape, Visant..) require the development of dedicated scripts.

We offer here a collection of such scripts, often with possibilities of integration between the scripts so that an input file can undergo a sequential transformation through different scripts in order to get to the desired result.

For details on the available operations, please see the documentation section

A web application written in Python by Andrea Cabibbo