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Paolo
Amati
Rome, University "La
Sapienza". Present projects in Amati's lab
include:
- Polyoma virus Large T oncogene interaction with
cell cycle control and in vitro muscle
differentiation.
- Expression of the autocrine loop of met kinase
receptor and its ligand HGF-SF in muscle cells
during active growth and differentation.
- Investigating the role of the Polyoma major
capsid protein VP1 in the regulation of early viral
gene expression through binding to host nuclear
matrix.
Phil
Andrews
The Andrews Lab,
University of Michigan, US. A Proteomics Group.
"One major focus of this laboratory has been the
development of new technologies for comprehensive
analysis of the responses of living cells to their
environment at the molecular level. In particular,
ones that can link protein structure information to
genome sequence. The initial goal has been to
achieve ultra-high throughput analysis of the
majority of the proteins present in cells"
Jean
Beggs
University of
Edimburgh , UK. " We are studying pre-mRNA splicing
in the yeast Saccharomyces cerevisiae. Pre-mRNA
splicing takes place in a very large RNA-protein
complex, the spliceosome, within which there are
several subparticles, each composed of a small
nuclear RNA (snRNA) and a set of proteins. During
spliceosome assembly and during the course of the
splicing reactions, many dynamic RNA-RNA
interactions occur and are apparently regulated by
proteins(...). We are investigating molecular
interactions in the spliceosome and identifying
novel splicing factors, using both biochemical and
genetic approaches, including in vitro
reconstitution of snRNPs, UV crosslinking and
two-hybrid interaction screens". The site hosts the
RNA
WebRing
Francesco
Blasi
DiBit-HSR,
Milano
The
Burton Group
At EBI. "We work in
the fied of Bioinformatics with an emphasis of the
analysis and prediction of protein
Structure"
Patrick
O. Brown
Stanford University.
The Brown Lab. Contains a complete
guide to microarraying for the molecular
biologist
Douglas
L. Brutlag
Stanford University.
The Brutlag Bioinformatics Group. "We are
interested in the problems of predicting biological
function of genes and proteins from their primary
sequence, predicting structure of protein and DNA
from its sequence, and understanding how and when
genes are expressed"
Neil
Bulleid
School of Biological
Sciences, Manchester, UK. Some
friends from Neil's Lab
Craig
M. Crews
Yale University. "The
broad interest of this lab is the chemical approach
to biological questions. Current projects explore
the mode of action of biologically active natural
products in order to investigate intracellular
signaling pathways and identify novel targets for
drug design"
Ivan
De Curtis
Cell motility requires the coordination of cell adhesion, membrane traffic and actin organization at the leading edge of the cell. Similar mechanisms are involved in neuritogenesis, during the migration of the growth cone in developing neurons. Our major focus is the identification and the analysis of the molecular networks coordinating the protrusive activity at the cell edge during cell migration and neurite extension.
Gabriel
Fenteany
Riccardo
Fesce
Reid
Gilmore
Stephen
High
School of Biological
Sciences, Manchester, UK. "The research in my
laboratory is aimed at understanding how proteins
are inserted into lipid bilayers to form
biologically functional membranes. Proteins must
first be targeted to the correct subcellular
compartment and then inserted into the membrane of
that compartment. Our studies concentrate on the
endoplasmic reticulum (ER) where a large number of
both integral membrane and secretory proteins are
synthesised"
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Ari
Helenius
Linda
Hendershot
Erwin
Ivessa
Armin
Lahm
The
Molecular Imaging
Group
At the Oak Ridge
National Laboratory (ORNL). Check out the
"Direct
Visualization of Regulatory Protein-DNA Complexes
and Mutations using Atomic Force
Microscopy" page.
Impressive DNA-protein interaction images
Ira
Mellman
Bruce
Nicholson
"Our laboratory is
interested in defining the structure and properties
of the unique class of membrane channels called gap
junctions that allow the direct passage of ions,
small metabolites and secondary messengers between
cells. The proteins that comprise these channels, a
family called connexins in the vertebrates , are
diverse in nature, with multiple members of the
family being expressed in most cells and
tissues"
Tom
Rapoport
Mariano
Rocchi
David
Ron
Michael
Snyder
Yale University
Pamela
Stanley Laboratory at Albert
Einstein
"Mammalian cells are coated with sugar glycans that
change in specific ways during embryonic
development, cell differentiation and
transformation into a cancer cell. The changes are
caused by the regulated expression of
glycosyltransferases that synthesize glycan units.
Understanding the biological consequences of sugar
changes at a molecular level defines the new field
of glycobiology. My lab is seeking to identify
molecules that recognize biologically relevant
glycan changes.We aim to discover new functions for
cell surface glycans by altering the expression of
specific glycosyltransferase genes in cells and in
mice."
Julie
Theriot
The Theriot Lab. This
lab have a MISSION
(possible). Check it out!
Anna
Tramontano
Antony
Watts
Director of the
Biomembrane
Structure Unit in
Oxford University, UK. The main research interests
of the Watts group focus on the study of the
structure of small molecules when at their site of
action in membrane-bound proteins whilst in their
native, fully functional form in membranes. In
addition, peptides which form channels in membranes
are being studied to high resolution using solid
state NMR methods.
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