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by: Veli Mäkinen, Djamal Belazzougui, Fabio Cunial, Alexandru I. Tomescu

 : Genome-Scale Algorithm Design: Biological Sequence Analysis in the Era of High-Throughput Sequencing
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Binding: Hardcover
EAN: 9781107078536
Edition: 1
ISBN: 1107078539
Item Dimensions: 99670921187
Label: Cambridge University Press
Languages: EnglishPublishedEnglishOriginal LanguageEnglishUnknown
Manufacturer: Cambridge University Press
Number Of Items: 1
Number Of Pages: 413
Publication Date: June 24, 2015
Publisher: Cambridge University Press
Studio: Cambridge University Press




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Editorial Review:

Product Description:
High-throughput sequencing has revolutionised the field of biological sequence analysis. Its application has enabled researchers to address important biological questions, often for the first time. This book provides an integrated presentation of the fundamental algorithms and data structures that power modern sequence analysis workflows. The topics covered range from the foundations of biological sequence analysis (alignments and hidden Markov models), to classical index structures (k-mer indexes, suffix arrays and suffix trees), Burrows-Wheeler indexes, graph algorithms and a number of advanced omics applications. The chapters feature numerous examples, algorithm visualisations, exercises and problems, each chosen to reflect the steps of large-scale sequencing projects, including read alignment, variant calling, haplotyping, fragment assembly, alignment-free genome comparison, transcript prediction and analysis of metagenomic samples. Each biological problem is accompanied by precise formulations, providing graduate students and researchers in bioinformatics and computer science with a powerful toolkit for the emerging applications of high-throughput sequencing.



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